J Clin Invest

Clustering of Mesothelioma Cases and Asbestos Exposure

When asbestos fibers are inhaled, they can attack the membranes surrounding the heart, lungs and abdomen and lead to disease development.  Mesothelioma alone causes the death of over 2,000 people each year.  Identifying the links between this deadly disease and asbestos exposure are important and ongoing.  One important study is called, “The epidermiologic relationship between pleural mesothelioma and asbestos exposure.” by Nurminen M. – Scand J Work Environ Health. 1975 Jun;1(2):128-37.  Here is an excerpt: “Abstract – This paper describes an investigation of 85 notifications of either probable or possible mesothelioma to the Finnish Cancer Registry from 1953 through 1969. The investigation covers characteristic epidemiologic features and the possibility of the mesothelioma being connected with occupational or other exposure to asbestos. The incidence rate of pleural mesothelioma was estimated at 1.1 per million per year. The male/female ratio was 1.3:1, which greatly differed fsrom that for malignant neoplasms of the bronchus or lung in Finland in 1960. The mean age at death from mesothelioma was over 7 years lower than that for bronchial carcinoma. The ratio of the crude incidence rates for the urban and rural populations was 4.2; the corresponding ratio for cases of carcinoma oopulations was 4.2; the corresponding ratio for cases of carcinoma of the bronchus or lung was 1.2 in Finland in 1960. The Last Occupations of the 82 Deceased Persons, Obtained from the Death Certificates, were Divided into Three Categories According to Possible Asbestos Exposure. Exposure was present or probable in 9 (11.0) cases, 28 (34.2 %) had a possible exposure, and in 33 (40.2 %) cases exposure was absent or unlikely. The occupation of 12 (14.6) persons was unknown. Additional information of possible exposure history was obtained by interviewing the relatives of 10 mesothelioma patients. For half of the persons a definite, although in some cases trivial, exposure to asbestos could be ascertained. For the other five persons no exposure, either occupational, neighborhood or domestic, to asbestos could be traced. The residental distribution of the 85 persons with mesothelioma revealed no clustering of cases.

A second article is called, “Restrictive lung function and asbestos-induced pleural fibrosis. A quantitative approach.” By D A Schwartz, J R Galvin, S J Yagla, S B Speakman, J A Merchant, and G W Hunninghake – J Clin Invest. 1993 June; 91(6): 2685–2692.   Here is an excerpt: “Abstract – To assess further the clinical significance of asbestos-induced pleural fibrosis, we used a computer algorithm to reconstruct images three dimensionally from the high-resolution computerized tomography (HRCT) scan of the chest in 60 asbestos-exposed subjects. Pulmonary function tests, chest radiographs, and HRCT scans were performed on all study subjects. The volume of asbestos-induced pleural fibrosis was computed from the three-dimensional reconstruction of the HRCT scan. Among those with pleural fibrosis identified on the HRCT scan (n = 29), the volume of the pleural lesion varied from 0.01% (0.5 ml) and 7.11% (260.4 ml) of the total chest cavity. To investigate the relationship between asbestos-induced pleural fibrosis and restrictive lung function, we compared the computer-derived estimate of pleural fibrosis to the total lung capacity and found that these measures were inversely related (r = -0.40; P = 0.002). After controlling for age, height, pack-years of cigarette smoking, and the presence of interstitial fibrosis on the chest radiograph, the volume of pleural fibrosis identified on the three-dimensional reconstructed image from the HRCT scan was inversely associated with the total lung capacity (P = 0.03) and independently accounted for 9.5% of the variance of this measure of lung volume. These findings further extend the scientific data supporting an independent association between pleural fibrosis and restrictive lung function.”  If you found any of these excerpts interesting, please read the studies in their entirety.

About the Author

Monty Wrobleski is the author of this article.  For more information please click on the following links

California Mesothelioma Lawyer,

Mesothelioma Lawyers San Diego,

Nephrogenic Systemic Fibrosis Attorney

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